What is Selank?
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed as an analog of the endogenous immunomodulatory peptide tuftsin. It exhibits anxiolytic, nootropic, and immunomodulatory properties in research models and has been studied for its effects on the GABAergic system and BDNF expression.
Selank Structure
| Peptide Name | Selank |
| Synonyms | TP-7 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | 751.88 g/mol |
Selank Research
1. Selank and Anxiolytic Effects
Research in animal models demonstrates significant anxiolytic effects for Selank, with mechanisms involving modulation of the GABAergic system and normalisation of IL-6 levels in stress models.
2. Selank and BDNF Expression
Studies have shown Selank increases BDNF (Brain-Derived Neurotrophic Factor) expression in the hippocampus and frontal cortex, relevant to neuroplasticity and cognitive research.
3. Selank and Immune Modulation
As a tuftsin analog, Selank enhances phagocytic activity and modulates T-cell-mediated immune responses in immunological research models.
Future Selank Research
Ongoing investigations target Selank in anxiety disorder models, post-traumatic stress research, and combined neuropeptide studies with Semax.
Selank Resources
- Semenova TP, et al. – Selank and its analogue – anxiolytic peptides. Ross Fiziol Zh Im I M Sechenova, 2009.
- Zozulya AA, et al. – Anxiolytic effects of a novel peptide drug Selank. Bull Exp Biol Med, 2001.


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