Semax 10mg

What is Semax?

Semax is a synthetic heptapeptide derived from the N-terminal fragment of ACTH(4-10) with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is a nootropic and neuroprotective research peptide that does not exhibit the hormonal effects of native ACTH, and has been extensively studied for its cognitive-enhancing and neurotrophic properties.

Semax Structure

Semax Research

1. Semax and BDNF/NGF Upregulation

Research demonstrates that Semax significantly upregulates BDNF and NGF (Nerve Growth Factor) in the hippocampus and cortex, supporting its use in neuroprotection and neuroplasticity research models.

2. Semax and Cognitive Enhancement

Animal studies show Semax improves working memory, learning, and attention in both normal subjects and ischemia models, attributed to its dopaminergic and serotonergic modulatory effects.

3. Semax and Neuroprotection

In stroke and ischemia research models, Semax has shown significant neuroprotective effects, reducing infarct volume and improving neurological outcomes.

Future Semax Research

Future research is investigating Semax in models of Parkinson’s disease, Alzheimer’s pathology, and traumatic brain injury recovery.

Semax Resources

• Mymrikov EV, et al. – The neuroprotective effects of Semax. Mol Biol, 2011.
• Dolotov OV, et al. – Semax, an analog of ACTH(4-7), regulates BDNF and NGF expression. J Neurochem, 2006.