MOTS-c 10mg

What is MOTS-c?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial genome. It has emerged as a significant regulator of metabolic homeostasis, with demonstrated effects on glucose utilisation, insulin sensitivity, and cellular stress responses.

MOTS-c Structure

MOTS-c Research

1. MOTS-c and Insulin Sensitivity

Preclinical studies demonstrate that MOTS-c administration improves insulin sensitivity by activating AMPK pathways and enhancing glucose uptake in skeletal muscle cells.

2. MOTS-c and Obesity Models

In high-fat diet mouse models, MOTS-c prevented obesity and reduced visceral fat accumulation, suggesting a role in regulating energy balance.

3. MOTS-c and Aging

Research shows MOTS-c levels decline with age. Exogenous administration in aged animal models has demonstrated restoration of metabolic function, positioning it as an important peptide in longevity research.

Future MOTS-c Research

Ongoing studies are investigating MOTS-c in the context of type 2 diabetes, age-related metabolic decline, exercise physiology, and mitochondrial disease models.

MOTS-c Resources

• Lee C, et al. – The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metabolism, 2015.
• Kim SJ, et al. – Mitochondrially derived peptides as novel regulators of metabolism. J Physiol, 2017.