IGF-1 LR3

What is IGF-1 LR3?

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a synthetic, elongated analog of human IGF-1, engineered with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. This modification significantly reduces binding to IGF-binding proteins, resulting in a substantially longer half-life compared to native IGF-1.

IGF-1 LR3 Structure

IGF-1 LR3 Research

1. IGF-1 LR3 and Muscle Cell Proliferation

Preclinical studies have demonstrated that IGF-1 LR3 promotes satellite cell activation and myoblast proliferation, making it a subject of interest in skeletal muscle biology research.

2. IGF-1 LR3 and Metabolic Signaling

Research indicates that IGF-1 LR3 activates the PI3K/Akt/mTOR signaling pathway more potently and for a longer duration than native IGF-1, due to reduced IGFBP binding.

3. IGF-1 LR3 and Cell Growth Models

In vitro studies utilize IGF-1 LR3 as a serum-free supplement for cell culture, supporting proliferation of various cell lines including muscle, liver, and neural cells.

Future IGF-1 LR3 Research

Ongoing investigations are exploring its role in tissue repair models, metabolic disorders, and age-related muscle wasting (sarcopenia). Researchers are also examining its interaction with growth hormone axes in controlled laboratory settings.

IGF-1 LR3 Resources

• Tomas FM, et al. – Prolonged effects of IGF-1 LR3 on nitrogen retention and muscle anabolism.
• Francis GL, et al. – Insulin-like growth factor analogues and their binding proteins.
• PubChem Compound Database – IGF-1 LR3 entry.